Chien-Chi Lin, Ph.D.
​Thomas J. Linnemeier Guidant Foundation Endowed Chair & Professor
Department of Biomedical Engineering, ​Purdue School of Engineering & Technology, 
​​​Indiana University-Purdue University Indianapolis
Education
2004-2007. Ph.D. Bioengineering, Clemson University, Clemson, SC. USA.
1996-1998. M.S. Chemical Engineering, National Taiwan University, Taipei, TAIWAN
1992-1996. B.S. Chemical Engineering, National TsingHua University, Hsingchu, TAIWAN
Positions
2020 -                 Thomas J. Linnemeier Guidant Foundation Endowed Chair & Professor, Department of Biomedical Engineering, IUPUI
2019 - 2020.      Thomas J. Linnemeier Guidant Foundation Fellow, IUPUI
2016 - 2020.      Associate Professor, Department of Biomedical Engineering, IUPUI
2010 - Present. Graduate Program Faculty, Weldon School of Biomedical Engineering, Purdue University
2012 - Present. Member, Indiana University Center for Diabetes & Metabolic Diseases (CDMD)
2012 - Present. Faculty Trainer, IU/Purdue Medical Scientist Training Program (MSTP)
2014 - Present. Member, Indiana University Simon Cancer Center (IUSCC)
2010 - 2016.      Assistant Professor, Department of Biomedical Engineering, IUPUI
2007 - 2010.      Postdoctoral Associate. Howard Hughes Medical Institute & University of Colorado, Boulder.
​2004 - 2007.      Graduate Research Assistant. Department of Bioengineering, Clemson University
Honors & Awards
2020             Thomas J. Linnemeier Guidant Foundation Endowed Chair, IUPUI
2019             Thomas J. Linnemeier Guidant Foundation Fellow, IUPUI
2018             Reviewer Excellence Award, Chemistry of Materials, American Chemical Society Publications​
2017             Abraham M. Max Distinguished Professor Award, Purdue School of Engineering & Technology, IUPUI
2016 - 2021 Honorary Scientist & Advisor on Agricultural Science & Technology, Rural Development Administration (Republic of Korea)​
2015             US Frontiers of Engineering Symposium Invited Attendee, National Academy of Engineering
2015             Faculty Early Career Development (CAREER) Award, National Science Foundation
2014             Purdue Summer Faculty Research Grant, Purdue Research Foundation
2013             Young Investigator Award, Frontiers in Bioengineering Workshop, Georgia Institute of Technology
2010             American Institute of Chemists Postdoctoral Award, University of Colorado 
2010             CO-Pilot Award, Colorado Clinical & Translational Sciences Institute 
2007             Outstanding Graduate Research Assistant Award, Graduate School & Clemson University Research Foundation
2007             Outstanding Graduate Researcher Award, College of Engineering & Science,Clemson University 
2007             Travel Award, Graduate Student Government, Clemson University
2007             Graduate Research Seminar Travel Award, Gordon Research Conference: Polymers (West)
2005             Travel Award, Graduate Student Government, Clemson University
1996             Wu Chung-Ya Scholarship, National Taiwan University, TAIWAN
Editorial Boards
  • Associate Editor, Frontiers in Bioengineering & Biotechnology (ISSN: 2296-4185)
  • Board member, ACS Biomaterials Science & Engineering (ISSN: 2373-9878)
  • Board member, Gels (ISSN 2310-2861)​​
​Patents & Invention Disclosure
  • Lin CC. “Visible light curable hydrogels and methods for using” US Patent No.: 9,364,543 (Patent granted on 06-14-2016)
  • Lin CC, Dawes CS, Konig H. “Stabilization of enzyme-immobilized hydrogels for extended hypoxic cell culture” US Patent No.: 11,124,761 (Patent granted on 09-21-2021).
  • Lin CC, Lin FY. “Synthesis of PEG-based thiol-norbornene hydrogels with tunable hydrolytic degradation properties” US Patent application, PCT/US22/15174. (Filed on 02-04-2021).
  • Lin CC, Lin FY. “Cytocompatible hydrogels and methods of making and using the same”. US Provisional Application Serial No. 63/334,804 (Filed on 04-26-2022)
  • Lin CC, Dimmitt NH. “Dissolvable iEDDA click hydrogels and methods of making and using the same.” US Provisional Application Serial No. 63/411,385 (Filed Sep 29, 2022)
  • Lin CC, Lin FY, Dimmitt NH. “Xeno-free PEHA polymers for 3D printing and methods of making and using the same”. US Provisional Application Serial No. 63/415,023 (Filed oct 11, 2022)
Active Grants
  • ​Thomas J. Linnemeier Guidant Foundation Endowment
  • Dynamic double network hydrogel for generating pancreatic organoids from induced pluripotent stem cells
​             NIH/NIDDK, R01 DK127436 (Role: PI. 08/2022-7/2026)
  • Gradient Hydrogels for Identifying Highly Invasive Pancreatic Cancer Cells
​             DoD/Pancreatic Cancer Research Program (Role: PI. 09/2022-9/2025)
  • BRAVE hydrogels for interrogating cell-matrix interactions in pancreatic desmoplasia
             NIH/NCI, R01 CA227737 (Role: PI. 12/2018-11/2022)
  • Engineering High-Fidelity Human Cochlear Organoids
             ​NIH/NIDCD, R01 DC020628 (Role: Co-I; PI Eri Hashino. 7/2022-6/2027)
  • Implant biofilm mediated immune response
             ​NIH/NIAID, R01 AI165958  (Role: Co-I; PI Mithun Sinha. 9/2022-8/2027)
  • Engineering multi-lineage human inner ear organoids 
​             NIH/NIDCD, R01 DC017461 (Role: Co-I; PI Karl Koehler. 12/2018-11/2023)​
Expired External Grants
  • A reversible dynamic hydrogel system for studying stemness and drug responsiveness of cancer stem cells. ​
​           NSF Faculty Early Career Development (CAREER) Award, DMR1452390 (Role: PI. 07/2015-06/2021)
  • ​A novel role for hypoxia and hypoxic gradients in the development of drug resistance and minimal residual disease in acute myeloid leukemia. Walther Cancer Foundation, Oncology Physical Sciences & Engineering Research Embedding Program Tier 2 Award (Co-PIs: Chien-Chi Lin, Mircea Ivan, Heiko Konig. 07/2019-12/2020) 
  • Development of a human islet graft model in diabetic db/db mice using injectable hydrogel encapsulation technology. ​​
​           Eli Lilly & Company (Role: PI. 12/2017-12/2019)​
  • A novel role for hypoxia and hypoxia gradients in the development of drug resistance & minimal residual disease in acute myeloid leukemia. Walther Cancer Foundation, Oncology Physical Sciences & Engineering Research Embedding Program Tier 1 Award (Co-PIs: Lin/Ivan/Konig. 03/2018-07/2018)
  • Delineating signaling pathways that coordinate the cytotoxic response of acute myeloid leukemia cells in the presence of hypoxic gradients. Lukemia and Lymphoma Society, New Idea Award (Role: Co-I. PI: Heiko Konig. 10/2016-09/2017)
  • ​Adaptable hydrogel platform to study pancreatic cancer. NIH/NCI, R21CA188911 (PI. ​07/2014-06/2017)
  • Preparation and characterization of SF-PEG hydrogel sheet for tissue engineering applications. Rural Development Administration, Republic of Korea (PI. 09/2014-12/2016)
  • Guanabenz and its Analog for Treatment of Bone Metastasis. 100 Voices of Hope for Breast Cancer Research (Co-I. PIs: Nakshatri/Yokota. 04/2014-03/2015)
  • Thiol-ene click hydrogels for in situ cell expansion and differentiation. NIH/NIBIB, R21EB013717 (PI. 07/2011-06/2014)​ ​
​
​Expired Internal Grants
  • Injectable nanocomposite hydrogels for sustained drug delivery. IUPUI Biomechanics & Biomaterials Research Center & Integrated Nanosystems Development Institute Pilot Grant (PI. 09/2017-08/2018)  ​​
  • Drug-releasing anti-inflammatory confomal coating for islet encapsulation. Indiana CTSI, Pilot Funding for Research Use of Core Facilities (PI. 01/2016-09/2018) ​
  • Visible light cured conformal coating for islet encapsulation and transplantation. IUPUI Biomechanics & Biomaterials Research Center Pilot Grant (PI. 01/2015-12/2016)
  • Potential liver stem cell-based liver engineering. ​IUPUI Biomechanics & Biomaterials Research Center Pilot Grant (Co-PI. Lin/Dai. ​04/2015-06/2016)
  • HIPPO pathway in hepatocellular carcinoma cells cultured in engineered 3D matrix. ​IUPUI Office of the Vice Chancellor for Research, Research Support Funds Grant (PI. 06/2015-06/2016)
  • Three-dimensional biomimetic hydrogels for functional liver tissue engineering. IU Office of the Vice President for Research, IU Collaborative Research Grant (Co-PI. Lin/Dai. 04/2014 – 09/2015)
  • Visible light cured hydrogels for simultaneous delivery of hydrophobic and hydrophilic drugs. IUPUI Office of the Vice Chancellor for Research, FORCES grant  (PI. 04/2014-11/2014)
  • Salubrinal-releasing orthopedic implants. IUPUI Office of the Vice Chancellor for Research, FORCES grant (Co-PI. Yokota/Lin. ​06/2012-04/2014) ​
  • Biomimetic hydrogel coating for enhancing immuno-isolation of pancreatic islets. Indiana Diabetes Research Center, Pilot & Feasibility Grant (PI. 04/2012-03/2014)
  • Synthetic niche for studying pancreatic cancer cell morphogenesis in 3D. IUPUI Biomechanics & Biomaterials Research Center Pilot Grant (PI. 01/2013-12/2013)
  • Enhance β-cell survival and function in autocrine-amplifying hydrogels. IUPUI Office of the Vice Chancellor for Research, Research Support Funds Grant (PI. 01/2011-11/2012)
  • Modular click hydrogels for dynamic 3D culture of mesenchymal stem cells. IUPUI Office of the Vice Chancellor for Research, Career support grant (PI. 09/2011-08/2012)
  • Biomaterial strategy to regulate local inflammation induced by the pro-inflammatory cytokines. Colorado CTSI, CO-Pilot Grant, UL1RR025780 (PI. 06/2010-05/2011)                           ​
​Teaching
BME381 Implantable Materials & Biological Response (2010-2013)
BME383 Problems in Implantable Materials & Biological Response (2011-2013) 
BME495 Tissue Engineering (2014, 2015, 2017)
BME595 Tissue Engineering (2011 - present)
BME595 Engineering Principles for Biomolecular Interactions (2014 - present)
BME595 Cancer Engineering (2021 - present)