Publications

Asterisk indicates corresponding author

Journal Covers

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Advanced Healthcare Materials 2022 (11) 2101284
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Journal of Materials Chemistry B 2020(8) 7835
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Advanced Healthcare Materials 2018 (7) 1800954
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Biomaterials Science 2017(5) 2231
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Macromolecular Bioscience 2016(16) 496
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Journal of Materials Chemistry B 2016(4)​ 4969
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Journal of Applied Polymer Science 2015(132) 41563
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Biomaterials Science 2014(2) 1063
  • Lin FY, Chang CY, Fishel M, Lin CC*. Viscoelastic hydrogels for interrogating pancreatic cancer-stromal cell interactions. 2022 (In revision)
  • Kim MH, Lin CC*. Poly(ethylene glycol)-norbornene as a photoclick bioink for digital light processing 3D bioprinting. ACS Applied Materials & Interfaces 2023 (In press)
  • Dimmitt NH, Arkenberg MR, Moraes de Lima Perini M, Li J, Lin CC*. Hydrolytically degradable PEG-based iEDDA click hydrogels. ACS Biomaterials Science & Engineering 2022 (8) 4262-4273
  • Arkenberg MR, Koehler K, Lin CC*. Gelatin-based hydrogels for culture and differentiation of induced pluripotent stem cells. Biomacromolecules 2022 (23) 4141-4152
  • (Invited Book Chapter) Arkenberg MR, Kim MH, Lin CC*. Click Chemistry for Biomedical Applications. In Multicomponent Hydrogels. Royal Society of Chemistry. 2022 
  • Sun X, Li KX, Figueiredo ML, Lin CC, Li BY, Yokota H*. Generation of the chondroprotective proteomes by activating PI3K and TNFα signaling. Cancers 2022 (14) 3039
  • Jiang Z, Lin FY, Jiang K, Chang CY, Yokota H, Lin CC*. Dissolvable microgel-templated macroporous hydrogels for controlled cell assembly. Biomaterials Advances 2022 (134) 112712 
  • Lin FY, Dimmitt NH, Moraes de Lima Perini M, Li J, Lin CC*. Injectable acylhydrazone hydrogels for sustained protein delivery. Advanced Healthcare Materials 2022 (11) 2101284
  • Liu S, Sun X, Li K, Lin CC, Na S, Li BY, Yokota H. Tumor cell secretomes in response to anti- and pro-tumorigenic agents. Onco 2021 (1) 101-113
  • Kim MH, Lin CC*. Norbornene-functionalized methylcellulose as a temperature and photo-responsive bioink. Biofabrication 2021 (13) 045023
  • Kim MH, Chang CY, Nguyen HD, Lin CC*. Dually functionalized gelatin for orthogonal and dynamic hydrogel crosslinking. ACS Biomaterials Science & Engineering 2021 (7) 4196 - 4208
  • Kim MH, Green SS, Lin CC*, Konig H*. Engineering tools for regulating hypoxia in tumor models. Journal of Cellular and Molecular Medicine 2021 (25) 7581-7592 
  • Chang CY, Johnson HC, Babb O, Fishel M, Lin CC*. Biomimetic stiffening of cell-laden hydrogels via sequential thiol-ene and hydrazone click reactions. Acta Biomaterialia 2021 (130) 161-171 
  • Kim MH, Lin CC*. Assessing monocyte phenotype in poly(γ-glutamic acid) hydrogels formed by orthogonal thiol-norbornene chemistry. Biomedical Materials 2021 (16) 045027 
  • Chang CY, Lin CC*. Hydrogel models with stiffness gradients for interrogating pancreatic cancer cell fate. Bioengineering 2021 (8) 37
  • Sun X, Li K, Zha R, Liu S, Fan Y, Wu D, Hase M, Aryal UK, Lin CC, Li BY, Yokota H*. Preventing tumor progression by induced tumor-suppressing MSCs. Theranostics 2021 (11) 5143-5159 
  • Lin FY, Lin CC*. Facile synthesis of rapidly degrading PEG-based thiol-norbornene hydrogels. ACS Macro Letters 2021 (10) 341-345 
  • ​Nguyen HD, Sun X, Yokota H, Lin CC*. Probing osteocyte functions in gelatin hydrogels with tunable viscoelasticity. Biomacromolecules 2021 (22) 1115-1126
  • Arkenberg MR, DImmitt NH, Johnson HC, Koehler KR, Lin CC*. Dynamic click hydrogels for xeno-free culture of induced pluripotent stem cells. Advanced Biosystems 2020 (4):e2000129
  • Arkenberg MR, Nguyen HD, Lin CC*. Recent advances in bio-orthogonal and dynamic crosslinking of biomimetic hydrogels. Journal of Materials Chemistry B 2020 (8) 7835-7855 - Featured on Journal Front Cover
  • (Invited Book Chapter)​ Macdougall L, Culver H, Lin CC, Bowman C, and Anseth KS*. Biodegradable and Resorbable Polymers. In Biomaterials Science: An Introduction to Materials in Medicine, 4th Ed. Elsevier Academic Press. 2020
  • Peuler KP, DImmitt NH, and Lin CC*. Clickable modular polysaccharide nanoparticles for selective cell-targeting. Carbohydrate Polymers 2020 (234) 115901​
  • Hudson BN, Dawes CS, Liu HY, DImmitt NH, Chen F, Konig H, Lin CC*. Stabilization of enzyme-immobilized hydrogels for extended hypoxic cell culture. Emergent Materials 2019 (2) 263-272
  • Liu HY and Lin CC*. A diffusion-reaction model for enzyme-mediated dynamic stiffening of PEG-peptide hydrogel. Gels 2019 (5) 17. 
  • Nguyen HD, Liu HY, Hudson BN, Lin CC*. Enzymatic crosslinking of dynamic thiol-norbornene click hydrogels. ACS Biomaterials Science & Engineering 2019 (5) 1247-1256
  • Arkenberg MR, Moore D, and Lin CC*. Dynamic control of hydrogel crosslinking via sortase-mediated reversible transpeptidation. Acta Biomaterialia 2019 (83) 83-95
  • Liu HY, Nguyen H, Lin CC*. Dynamic PEG-peptide hydrogels via visible light and FMN-induced tyrosine dimerization. Advanced Healthcare Materials 2018 (7) 1800954 - Featured on Journal Front Cover
  • Lin CC*, Korc M. Designer hydrogels: Shedding light on the physical chemistry of the pancreatic cancer microenvironment. Cancer Letters 2018 (436) 22-27
  • Liu HY, Korc M, and Lin CC*. Biomimetic and enzyme-responsive dynamic hydrogels for studying cell-matrix interactions in pancreatic ductal adenocarcinoma. Biomaterials 2018 (160) 24-36
  • (Invited Book Chapter) Lin CC*. Synthetic Hydrogels for 3D Cell Culture. Hydrogels: Design, Synthesis & Application in Drug Delivery & Regenerative Medicine.  Editors: Singh T, Donnelly R, Laverty G. CRC Press. 2018 (ISBN: 978-149-8748-61-2) ​
  • Arkenberg MR and Lin CC*. Orthogonal enzymatic reactions for rapid crosslinking and dynamic tuning of PEG-peptide hydrogels.
    Biomaterials Science 2017 (5) 2231-2240 - Featured on Journal Front Cover
  • Dawes CS, Konig H, and Lin CC*. Enzyme-immobilized hydrogels to create hypoxic environment for in vitro cancer cell culture. Journal of Biotechnology 2017 (248) 25-34
  • Elhashmi A, Alvarez MB, Bragg JC, Childress PJ, Himes ER, Greene T, Goebel WS, Kacena, MA, Lin CC, and Chu TMG*. A fast-degrading thiol-acrylate based hydrogel for cranial regeneration. Biomedical Materials 2017 (12) 025011
  • Shih H, Liu HY, and Lin CC*. Improving gelation efficiency and cytocompatibility of visible light polymerized thiol-norbornene hydrogels via addition of soluble tyrosine. Biomaterials Science 2017 (5) 589-599​
  • Greene T, Lin TY, Andrisani O, and Lin CC*. Comparative study of visible light polymerized gelatin hydrogels for 3D culture of hepatic progenitor cells. Journal of Applied Polymer Science 2017 (134) 44585
  • Liu HY, Greene T, Lin TY, Dawes CS, Korc M, and Lin CC*. Enzyme-mediated stiffening hydrogels for probing activation of pancreatic stellate cells. Acta Biomaterialia 2017 (48) 258-269 ​
  • Shih H, Greene T, Korc M, and Lin CC*. Modular and adaptable tumor niche prepared from visible light-initiated thiol-norbornene photopolymerization. Biomacromolecules 2016 (17) 3872-3882
  • Bragg JC, Jo YY, Lee KG, Kweon HY, and Lin CC*. In situ forming silk-gelatin hybrid hydrogels for affinity-based growth factor sequestration and release. RSC Advances 2016 (6) 114353-114360 
  • Xu W, Chen A, Zhang Y, Li J, Lin CC, Yan J, and Yokota H*. Hydrogel-based local release of salubrinal stimulates healing of mouse tibia fracture. Orthopedic & Muscular System: Current Research​ 2016 (5) 1000220.
  • Shih H and Lin CC*. Tuning stiffness of cell-laden hydrogels via host-guest interaction. Journal of Materials Chemistry B 2016 (4)​4969-4974​ - Featured on Journal Front Cover 
  • Ryu S, Kim HH, Park YH, Lin CC, Um IC, Ki CS*. Dual mode gelation behavior of silk fibroin microgel embedded poly(ethylene glycol) hydrogel. Journal of Materials Chemistry B 2016 (4) 4574-4584
  • Lin TY, Bragg JC, and Lin CC*. Designing visible light cured thiol-acrylate hydrogels for studying HIPPO pathway activation in hepatocellular carcinoma cells. Macromolecular Bioscience 2016(16) 496-507 (Equal contribution) - Featured on Journal Back Cover
  • Jo YY, Lee KW, Bragg JC, Lin CC, and HY Kweon*. Structural and thermal characteristics of photocrosslinked silk fibroin-PEG hydrogel. International Journal of Industrial Entomology 2016(32) 35-40. 
  • Bragg JC, Jo YY, Lee KG, Kweon HY, and Lin CC*. Modulating mechanical properties of chemically crosslinked PEG hydrogels via physical entrapment of silk fibroin. ​Journal of Applied Polymer Science 2016(133) 43075 - Highlighted on MaterialsView: Making better PEG hydrogels with help from silk fibroin
  • (Invited Book Chapter) Lin CC* and Shih H. Modeling drug release from synthetic hydrogels. Gels Handbook: Fundamentals, Properties and Applications. Editors: Demirci U and Khademhosseini A. 2016 (ISBN: 978-981-4656-10-8) World Scientific Publishing Company. ​​
  • (Invited Book Chapter) Shih H and Lin CC*. Dynamic Control of Degradable Thiol-ene Hydrogels. Biodegradable Polymers: New Biomaterial Advancement and Challenges. Editor: Chu CC. Nova Science Publishers. 2015 ( ISBN: 978-1-63483-652-4)
  • Greene T and Lin CC*. Modular crosslinking of gelatin-based thiol-ene hydrogels for in vitro culture of hepatocellular carcinoma cells. ACS Biomaterials Science & Engineering 2015(1) 1314-1323
  • Shih H and Lin CC*. Photoclick hydrogels prepared from functionalized cyclodextrin and poly(ethylene glycol) for drug delivery and in situ cell encapsulation. Biomacromolecules 2015(16) 1915-1923
  • Lin CC*. Recent advances in crosslinking chemistry of biomimetic poly(ethylene glycol) hydrogels. RSC Advances 2015(5) 39844-398583
  • Shih H, Mirmira RG, and Lin CC*. Visible light-initiated interfacial thiol-ene photopolymerization for forming islet surface conformal coating. Journal of Materials Chemistry B 2015(3) 170-175
  • Lin CC*, Ki CS, Shih H. Thiol-norbornene photo-click hydrogels for tissue engineering applications. Journal of Applied Polymer Science 2015(132) 41563 - Featured on Journal Front Cover
  • ​Ki CS, Lin TY, Korc M, and Lin CC*. Thiol-ene hydrogels as desmoplasia-mimetic matrices for modeling pancreatic cancer cell growth, invasion, and drug resistance. Biomaterials 2014(35) 9668-9677
  • Lin TY, Ki CS, and Lin CC*. Manipulating hepatocellular carcinoma cell fate in orthogonally cross-linked hydrogels. Biomaterials 2014(35) 6898-6906
  • Munoz Z, Shih H, and Lin CC*.Gelatin hydrogels formed by orthogonal thiol-norbornene photochemistry for cell encapsulation. Biomaterials Science 2014(2) 1063-1072 (Equal contribution) - Featured on Journal Front Cover
  • Fraser AK, Ki CS, and Lin CC*. PEG-based microgels formed by visible light mediated thiol-ene photo-click reactions.
    Macromolecular Chemistry & Physics 2014(215) 507-515 (Equal contribution)
  • Hao Y and Lin CC*. Degradable thiol-acrylate hydrogels as tunable matrices for 3D hepatic culture. Journal of Biomedical Materials Research: Part A 2014(102) 3813-3827
  • Hao Y, Shih H, Munoz Z, Kemp A, Lin CC*. Visible light cured thiol-vinyl hydrogels with tunable degradation for 3D cell culture. Acta Biomaterialia 2014(10) 104-114 (Equal contribution)
  • (Invited Book Chapter) Lin CC*. Functionalized poly(ethylene glycol) hydrogels for controlling stem cell fate. Biomaterials and Regenerative Medicine Editor: Ma PX. Cambridge University Press. 2014 (ISBN: 978-1107012097)​
  • Hamamura K, Zhang P, Zhao L, Shim JW, Chen A, Dodge TR, Wan Q, Shih H, Na S, Lin CC, Sun HB, and Yokota H*. Knee loading reduces MMP13 activity in the mouse cartilage. BMC Musculoskeletal Disorders 2013(14) 312. 
  • Ki CS, Shih H, and Lin CC*. Effect of 3D matrix compositions on the efficacy of EGFR inhibitor in pancreatic ductal adenocarcinoma cells. Biomacromolecules 2013(14) 3017-3026
  • Raza A and Lin CC*. The influence of hydrogel degradation and functionality on cell survival and morphogenesis in PEG-based hydrogels. Macromolecular Bioscience 2013(13) 1048-1058
  • Raza A, Ki CS, and Lin CC*.  The influence of matrix properties on growth and morphogenesis of pancreatic ductal epithelial cell in 3D. Biomaterials 2013(34) 5117-5127 
  • Hamamura K, Lin CC, and Yokota H*. Salubrinal reduces expression and activity of MMP13 in chondrocytes. Osteoarthritis & Cartilage 2013(21) 764-772
  • Ki CS, Shih H, and Lin CC*. Facile preparation of photodegradable hydrogels by photopolymerization. Polymer 2013(54) 2115-2122
  • Shih H, Fraser AK, and Lin CC*. Interfacial thiol-ene photo-click reactions for forming multilayer hydrogels. ACS Applied Materials & Interfaces 2013(5) 1673-1680
  • Shih H and Lin CC*. Visible light-mediated thiol-ene hydrogelation using eosin-Y as the only photoinitiator. Macromolecular Rapid Communications 2013(34) 269-273
  • (Invited Book Chapter) Lin CC, Anseth KS*. Biodegradation of Biodegradable Polymeric Biomaterials. Biomaterials Science: An Introduction to Materials in Medicine, 3rd Ed. Editors: Ratner BD, Hoffman AS, Schoen FJ, and Lemons JE. Elsevier Academic Press. 2013 (ISBN: 978-0123746269) 
  • ​Raza A and Lin CC*. Generation and recovery of β-cell spheroids from step-growth PEG-peptide hydrogels. Journal of Visualized Experiments 2012(70) e50081
  • Shih H and Lin CC*. Crosslinking and degradation of step-growth hydrogels formed by thiol-ene photo-click chemistry. Biomacromolecules 2012(13) 2003-2012
  • Lin CC*, Raza A, Shih H. PEG hydrogels formed by thiol-ene photo-click chemistry and their effect on the formation and recovery of insulin-secreting cell spheroids. Biomaterials 2011(32) 9685-9695​​

| Prior to 2010 (Pre- & Post-doctoral periods)

  • Lin CC* and Anseth KS*. Cell-cell communication mimicry with PEG hydrogels for enhancing β-cell function. The Proceedings of the National Academy of Sciences USA 2011(108) 6380-6385. - Highlighted on Nature SciBX 4(16).
  • Bernard AB, Lin CC, Anseth KS*. A microwell cell culture platform for the aggregation of pancreatic β-cells. Tissue Engineering, Part C 2012(18) 583-592. 
  • McCall JD, Lin CC, Anseth KS*. Affinity peptides protect transforming growth factor beta during encapsulation in poly(ethylene glycol) hydrogels. Biomacromolecules 2011(12) 1051-1057.
  • Anderson SB, Lin CC, Kuntzler DV, Anseth KS*. The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels. Biomaterials 2011(32) 3564-3574. 
  • Aimetti AA, Shoemaker RK, Lin CC, Anseth KS*. On-resin peptide macrocyclization using thiol-ene click chemistry. Chemical Communications 2010(46) 4061-4063.  
  • Lin CC, Boyer PD, Aimetti AA, Anseth KS*. Regulating MCP-1 diffusion in affinity hydrogels for enhancing immuno-isolation. Journal of Controlled Release 2010(142) 384-391. 
  • Lin CC, Metters AT, Anseth KS*. Functional PEG-peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNFα. Biomaterials 2009(30) 4907-4914.  
  • Lin CC and Anseth KS*. Glucagon-like peptide-1 functionalized PEG hydrogels promote survival and function of  encapsulated pancreatic β-cells. Biomacromolecules 2009(10) 2460-2467.
  • ​Lin CC and Anseth KS*. Controlling affinity binding in peptide functionalized poly(ethylene glycol) hydrogels. Advanced Functional Materials 2009(19) 2325-2331. 
  • ​Lin CC and Anseth KS*. PEG hydrogels for the controlled release of biomolecules in regenerative medicine. Pharmaceutical Research 2009(26) 631-643.
  • Lin CC and Metters AT*. Bifunctional monolithic affinity hydrogels for dual-protein delivery. Biomacromolecules 2008(9) 789-795.
  • ​Lin CC, Sawicki SM, Metters AT. Free-radical-mediated protein inactivation and recovery during protein photoencapsulation. Biomacromolecules 2008(9) 75-83. 
  • Lin CC and Metters AT*.  Metal-chelating affinity hydrogels for sustained protein release. Journal of Biomedical Materials Research: Part A 2007(83) 954-964.
  • (Invited Book Chapter) Metters AT* and Lin CC. Biodegradable hydrogels: Tailoring properties and function through chemistry and structure. Biomaterials. Editors: Wong JY and Bronzino JD. CRC Press. 2007 (ISBN-13: 978-0849378881) 
  • Lin CC and Metters AT*. Hydrogels for controlled release formulations – Network design and mathematical modeling. Advanced Drug Delivery Reviews 2006(58) 1379-1408.
  • Lin CC and Metters AT*. Enhanced protein delivery from photopolymerized hydrogels using a pseudo-specific metal chelating ligand. Pharmaceutical Research 2006(23) 614-622. 
  • Lin CC, Co CC, Ho CC*. Micropatterning proteins and cells on Polylactic acid and poly(lactide-co-glycolide). Biomaterials 2005(26) 3655-3662.​